{"id":894,"date":"2023-05-10T20:15:14","date_gmt":"2023-05-10T18:15:14","guid":{"rendered":"https:\/\/www.canceropole-grandouest.com\/?page_id=894"},"modified":"2025-04-02T12:20:48","modified_gmt":"2025-04-02T10:20:48","slug":"groupe-de-travail","status":"publish","type":"page","link":"https:\/\/www.canceropole-grandouest.com\/3mc\/groupe-de-travail\/","title":{"rendered":"Th\u00e9matiques du r\u00e9seau 3MC"},"content":{"rendered":"\r\n<h2>Les th\u00e9matiques du r\u00e9seau sont les suivantes :<\/h2>\r\n<ul>\r\n<li>la recherche de nouvelles cibles biologiques impliqu\u00e9es dans le cancer telles que les kinases du cycle cellulaire et des voies de signalisation.<\/li>\r\n<li>le d\u00e9veloppement d&#8217;agents anticanc\u00e9reux issus ou d\u00e9riv\u00e9s du milieu marin, essentiellement des mol\u00e9cules h\u00e9t\u00e9rocycliques, macrocycliques, des alkylglyc\u00e9rols et des glycoconjugu\u00e9s, synth\u00e9tis\u00e9es par des laboratoires de chimie organique, actives directement sur ces cibles ou sur l&#8217;environnement tumoral<\/li>\r\n<li>l&#8217;\u00e9tude de l&#8217;implication de canaux ioniques et complexes dans la progression tumorale et la r\u00e9ponse th\u00e9rapeutique afin d&#8217;identifier de nouvelles cibles et\/ou biomarqueurs et le d\u00e9veloppement de leur modulateurs.<\/li>\r\n<li>l&#8217;\u00e9tude de la reprogrammation m\u00e9tabolique par l&#8217;identification des alt\u00e9rations mitochondriales associ\u00e9es avec l&#8217;agressivit\u00e9 des cellules tumorales et avec les dysfonctions m\u00e9taboliques des cellules non canc\u00e9reuses dans le contexte de la cachexie canc\u00e9reuse ainsi que le potentiel th\u00e9rapeutique de la modulation de certaines propri\u00e9t\u00e9s mitochondriales.<\/li>\r\n<\/ul>\r\n","protected":false},"excerpt":{"rendered":"<p>Les th\u00e9matiques du r\u00e9seau sont les suivantes : la recherche de nouvelles cibles biologiques impliqu\u00e9es dans le cancer&#8230;<\/p>\n","protected":false},"author":1,"featured_media":188,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-894","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - 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