{"id":1091,"date":"2023-11-21T16:27:01","date_gmt":"2023-11-21T15:27:01","guid":{"rendered":"https:\/\/www.canceropole-grandouest.com\/shs\/?page_id=1091"},"modified":"2025-04-03T13:50:47","modified_gmt":"2025-04-03T11:50:47","slug":"projets-en-cours","status":"publish","type":"page","link":"https:\/\/www.canceropole-grandouest.com\/shs\/projets-en-cours\/","title":{"rendered":"Projets en cours"},"content":{"rendered":"\r\n<h4>Au travers de ses appels d&#8217;offres le Canc\u00e9rop\u00f4le Grand Ouest soutient actuellement les projets suivants :<\/h4>\r\n<ul>\r\n<li>Le\u00a0<strong>projet Structurant Stro-TARGET<\/strong>\u00a0(AOS R\u00e9gions 2022)\u00a0<em>Targeting stromal remodeling to improve anticancer treatments<\/em>, port\u00e9 par Olivier H\u00e9rault et regroupant 4 \u00e9quipes du r\u00e9seau NET.<br \/>Objectif principal du projet\u00a0:En caract\u00e9risant les anomalies de m\u00e9thylation de l&#8217;ADN dans les cellules stromales ayant un impact sur leur fonctionnalit\u00e9 (m\u00e9tabolisme, s\u00e9cr\u00e9tome&#8230;), le projet STRO-TARGET vise \u00e0 am\u00e9liorer la chimiosensibilit\u00e9 des cancers en identifiant les anomalies spontan\u00e9es et induites par les traitements dans le microenvironnement tumoral qui peuvent \u00eatre cibl\u00e9es par des traitements sp\u00e9cifiques compl\u00e9mentaires \u00e0 la chimioth\u00e9rapie de r\u00e9f\u00e9rence.<\/li>\r\n<li><strong>Emergence inter-r\u00e9seaux NET et SHS<\/strong>\u00a0(AOE 2023) EpiSPORT : Sport et \u00e9pig\u00e9n\u00e9tique : vers une prise en charge personnalis\u00e9e du cancer du sein. Ce projet est port\u00e9 par Jos\u00e9phine Briand (r\u00e9seau NET) et Stacey Johnson (r\u00e9seau SHS).<\/li>\r\n<li><strong>Emergence inter-r\u00e9seaux NET et 3MC<\/strong>\u00a0(AOE 2023) KCNN2THERANO : KCNN2, une cible th\u00e9ranostique ? Ce projet est port\u00e9 par Pierre-Fran\u00e7ois Cartron (r\u00e9seau NET) et Christophe Vandier (r\u00e9seau 3MC).<\/li>\r\n<li><strong>Emergence inter-r\u00e9seaux NET et 3MC<\/strong>\u00a0(AOE 2024) Ago-ALMIC : Synth\u00e8se d&#8217;agonistes de l&#8217;ALDH2 pour la reprogrammation m\u00e9tabolique du microenvironnement m\u00e9dullaire expos\u00e9 aux pesticides. Ce projet est port\u00e9 par Am\u00e9lie Foucault (r\u00e9seau NET) et Fr\u00e9d\u00e9ric Buron (r\u00e9seau 3MC).<\/li>\r\n<li><strong>Emergence inter-r\u00e9seaux NET et CasTHor<\/strong>\u00a0(AOE 2024) IMACALSEQCAP : Imagerie calcique et s\u00e9quen\u00e7age \u00e0 longue lecture en cellule unique pour l&#8217;\u00e9tude de l&#8217;interaction des cellules canc\u00e9reuses prostatiques et leur micro-environnement. Ce projet est port\u00e9 par Thomas Derrien (r\u00e9seau NET) et David Crott\u00e8s (r\u00e9seau CasTHor).<\/li>\r\n<\/ul>\r\n<h4>Le Canc\u00e9rop\u00f4le a soutenu depuis 2016 les projets suivants\u00a0:<\/h4>\r\n<ul>\r\n<li>Le\u00a0<strong>projet Structurant lncRESIST<\/strong>\u00a0(2020-2023)\u00a0<em>Functional CRISPR screens to identify lncRNAs conferring drug resistance in four solid cancers (melanoma, lung, cancer, prostate cancer and glioma)<\/em>, port\u00e9 par David Gilot puis Remy Pedeux.<\/li>\r\n<li>Le\u00a0<strong>projet Structurant NuPAC<\/strong>\u00a0(2020-2023)\u00a0<em>Impact of Nutrition and Physical Activity on predictive Cancer biomarkers<\/em>, port\u00e9 par Pierre-Fran\u00e7ois Cartron.<\/li>\r\n<li>Le p<strong>rojet Structurant PeNiCa<\/strong>\u00a0(2016-2019), port\u00e9 par Olivier H\u00e9rault, regroupe cinq \u00e9quipes du r\u00e9seau NET et s&#8217;int\u00e9resse aux effets d&#8217;un m\u00e9lange de pesticides \u00e0 faibles doses sur les cellules souches et stromales des niches. L&#8217;objectif est d&#8217;\u00e9tudier l&#8217;impact de ses pesticides sur la progression, l&#8217;invasion et la chimior\u00e9sistance des tumeurs.<\/li>\r\n<li>Le\u00a0<strong>projet Structurant ExomiR<\/strong>\u00a0(2018-2021), port\u00e9 par Delphine Fradin, regroupe onze \u00e9quipes du r\u00e9seau NET, et avait pour objectif d&#8217;\u00e9tudier le contenu en micro-ARNs des exosomes du microenvironnement des cancers. Les exosomes sont des v\u00e9sicules issues des cellules tumorales servant \u00e0 la communication intercellulaire. Leur contenu permet ainsi de moduler l&#8217;expression des g\u00e8nes de la cellule r\u00e9ceptrice. Ce projet a permis un tremplin \u00e0 un projet SIGN&#8217;IT financ\u00e9 par la Fondation ARC.<\/li>\r\n<li>L&#8217;<strong>appel d&#8217;offre Emergence 2018<\/strong>\u00a0a \u00e9t\u00e9 attribu\u00e9 \u00e0 Aur\u00e9lien S\u00e9randour pour son projet, visait \u00e0 mettre en \u00e9vidence les acteurs \u00e9pig\u00e9n\u00e9tiques \u00e0 l&#8217;origine de la r\u00e9sistante acquise au T\u00e9mozolomide via une approche innovante de CRISPR Knock-Out ou CRISPR-activation. Cet outil technique peut \u00eatre partag\u00e9 avec la communaut\u00e9 du CGO.<\/li>\r\n<li>Le projet laur\u00e9at de l&#8217;<strong>appel d&#8217;offre commun CGO\/AstraZeneca\u00a0<\/strong>(2017-2020), port\u00e9 par Pierre-Fran\u00e7ois Cartron, a permis de mettre en \u00e9vidence des marques \u00e9pig\u00e9n\u00e9tiques associ\u00e9es \u00e0 la r\u00e9sistance au traitement PARP inhibiteur dans le cadre du cancer de l&#8217;ovaire.<\/li>\r\n<\/ul>\r\n","protected":false},"excerpt":{"rendered":"<p>Au travers de ses appels d&#8217;offres le Canc\u00e9rop\u00f4le Grand Ouest soutient actuellement les projets suivants : Le\u00a0projet Structurant&#8230;<\/p>\n","protected":false},"author":2,"featured_media":215,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-1091","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Projets en cours - Sciences Humaines et Sociales (SHS)<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.canceropole-grandouest.com\/shs\/projets-en-cours\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Projets en cours - Sciences Humaines et Sociales (SHS)\" \/>\n<meta property=\"og:description\" content=\"Au travers de ses appels d&#8217;offres le Canc\u00e9rop\u00f4le Grand Ouest soutient actuellement les projets suivants : Le\u00a0projet Structurant...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.canceropole-grandouest.com\/shs\/projets-en-cours\/\" \/>\n<meta property=\"og:site_name\" content=\"Sciences Humaines et Sociales (SHS)\" \/>\n<meta property=\"article:modified_time\" content=\"2025-04-03T11:50:47+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.canceropole-grandouest.com\/shs\/wp-content\/uploads\/sites\/9\/2023\/04\/Pastille-Reseau-SHS-web.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"800\" \/>\n\t<meta property=\"og:image:height\" content=\"487\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.canceropole-grandouest.com\/shs\/projets-en-cours\/\",\"url\":\"https:\/\/www.canceropole-grandouest.com\/shs\/projets-en-cours\/\",\"name\":\"Projets en cours - Sciences Humaines et Sociales (SHS)\",\"isPartOf\":{\"@id\":\"https:\/\/www.canceropole-grandouest.com\/shs\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.canceropole-grandouest.com\/shs\/projets-en-cours\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.canceropole-grandouest.com\/shs\/projets-en-cours\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.canceropole-grandouest.com\/shs\/wp-content\/uploads\/sites\/9\/2023\/04\/Pastille-Reseau-SHS-web.jpg\",\"datePublished\":\"2023-11-21T15:27:01+00:00\",\"dateModified\":\"2025-04-03T11:50:47+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.canceropole-grandouest.com\/shs\/projets-en-cours\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.canceropole-grandouest.com\/shs\/projets-en-cours\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/www.canceropole-grandouest.com\/shs\/projets-en-cours\/#primaryimage\",\"url\":\"https:\/\/www.canceropole-grandouest.com\/shs\/wp-content\/uploads\/sites\/9\/2023\/04\/Pastille-Reseau-SHS-web.jpg\",\"contentUrl\":\"https:\/\/www.canceropole-grandouest.com\/shs\/wp-content\/uploads\/sites\/9\/2023\/04\/Pastille-Reseau-SHS-web.jpg\",\"width\":800,\"height\":487},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.canceropole-grandouest.com\/shs\/projets-en-cours\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/www.canceropole-grandouest.com\/shs\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Projets en cours\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.canceropole-grandouest.com\/shs\/#website\",\"url\":\"https:\/\/www.canceropole-grandouest.com\/shs\/\",\"name\":\"Sciences Humaines et Sociales (SHS)\",\"description\":\"Bretagne. 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