Les publications

Image-guided radiotherapy (IGRT) has become a standard irradiation technique to improve the clinical outcome of patients in terms of toxicity and local control due to better targeting of radiation during the irradiation fraction. Positioning imaging systems, whether embedded or not, such as kV for 2×2D acquisitions and especially kVCBCT for 3D acquisitions are however irradiating in a large volume including the target volume but also healthy tissue, with a theoretical risk of increased toxicity and second cancer.

The positron emitter 52gMn is used for the Positron Emission Tomography – PET imaging.In this work we investigate the nuclear reactions for production of 52gMn and 54Mn induced by deuteron beams on natural chromium targets at energies up to Ed = 28 MeV using the stacked-foils activation technique.

Personalized medicine aims at offering optimized treatment options and improved survival for cancer patients based on individual variability. The success of precision medicine depends on robust biomarkers.

Plusieurs modèles existent pour prédire le risque d’envahissement ganglionnaire pelvien mais aussi le risque de récidive biologique après prostatectomie dans le cancer de prostate localisé. Ces scores ont été validés dans des populations en majorité caucasienne. Peu de données sont disponibles pour les populations d’ascendance africaine.

La récidive biologique d’un adénocarcinome de prostate après irradiation est définie selon les critères de Phoenix. Il est nécessaire de prouver une récidive histologique par des biopsies. Le but de cette étude est d’analyser la localisation des récidives et de comparer les biopsies prostatiques transpérinéales en saturation et ciblées, aux index tumoraux (IT) défini sur l’IRM et par le TDM-TEP à la 18F-choline (TEPc).

Over the past two decades, quantitative proteomics has emerged as an important tool for deciphering the complex molecular events involved in cancers. The number of references involving studies on the cancer metastatic process has doubled since 2010, while the last 5 years have seen the development of novel technologies combining deep proteome coverage capabilities with quantitative consistency and accuracy.

The imbalance between BCL-2 homologues and pro-death counterparts frequently noted in cancer cells endows them with a cell autonomous survival advantage. To eradicate ectopic cells, inhibitors of these homologues (BH3 mimetics) were developed to trigger, during anticancer treatment, full activation of the canonical mitochondrial apoptotic pathway and related caspases.

Background: Targeted therapies such as BRAF and MEK inhibitors and immunotherapies have been made available to treat melanoma.

Objectives: To provide an overview of the management of the French Stage III melanoma population after complete lymph node resection prior to new adjuvant therapies.