Les publications

Purpose: The aim of this study was to compare retrospectively 18F-DOPA PET/CT versus 68Ga-DOTANOC PET/CT in a group of patients affected by midgut NET.

Patients and methods: Patients with histologically proven grade 1 or grade 2 midgut NET were explored after injection of 150 MBq of 68Ga-DOTANOC and 210 MBq of 18F-DOPA. The PET/CTs were analyzed visually and semiquantitatively at the patient level, regional level (7 defined regions), and lesion level (maximum of 5 lesions/organ).

Les modalités de surveillance active (SA) d’un adénocarcinome prostatique (CaP) de faible risque intègrent dorénavant les données de l’IRM pour le calcul de la densité du PSA (PSAd) et la réalisation de biopsies ciblées. Le but de cette étude était d’évaluer la proportion de patients pouvant bénéficier d’une SA en fonction de critères pré-biopsiques comme le résultat de l’IRM et la densité du PSA.

Image-guided radiotherapy (IGRT) has become a standard irradiation technique to improve the clinical outcome of patients in terms of toxicity and local control due to better targeting of radiation during the irradiation fraction. Positioning imaging systems, whether embedded or not, such as kV for 2×2D acquisitions and especially kVCBCT for 3D acquisitions are however irradiating in a large volume including the target volume but also healthy tissue, with a theoretical risk of increased toxicity and second cancer.

(Chemo)-radiotherapy (RT) is the gold standard treatment for patients with locally advanced lung cancer non accessible for surgery. However, current toxicity prediction models rely on clinical and dose volume histograms (DVHs) and remain unsufficient.

Purpose: To evaluate the potential benefit of using alternative reconstruction schemes of PET images for the prognostic value of radiomic features.

Methods: Patients (n=91) with non-small cell lung cancer were prospectively included. All had a PET/CT examination before treatment.

Oncotype DX® assay is used to guide therapeutic decisions in early-stage invasive breast carcinoma but remains expensive. Magee Equations (MEs) and Magee Decision Algorithm (MDA) predict the Oncotype DX® recurrence score (RS) on the basis of histopathological parameters.

Nanomedicine implication in cancer treatment and diagnosis studies witness huge attention, especially with the promising results obtained in preclinical studies. Despite this, only few nanomedicines succeeded to pass clinical phase.

The levels and composition of sphingolipids and related metabolites are altered in aging and in common disorders such as diabetes and cancers, as well as in neurodegenerative, cardiovascular, and respiratory diseases.

Plusieurs modèles existent pour prédire le risque d’envahissement ganglionnaire pelvien mais aussi le risque de récidive biologique après prostatectomie dans le cancer de prostate localisé. Ces scores ont été validés dans des populations en majorité caucasienne. Peu de données sont disponibles pour les populations d’ascendance africaine.