Les publications

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398 publications
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Sphingolipid distribution at mitochondria-associated membranes (MAMs) upon induction of apopt

The levels and composition of sphingolipids and related metabolites are altered in aging and in common disorders such as diabetes and cancers, as well as in neurodegenerative, cardiovascular, and respiratory diseases.

  • Ref: doi: 10.1194/jlr.RA120000628
  • Année de publication : 2020
  • Auteurs : Mignard V, Dubois N, Lanoé D, Joalland MP, Oliver L, Pecqueur C, Heymann D, Paris F, Vallette FM, Lalier L. J Lipid Res.
  • Réseaux : Réseaux: « Molécules Marines, Métabolisme et Cancer » & « Vectorisation, Imagerie, Radiothérapies »
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Microbiota and cancer: In vitro and in vivo models to evaluate nanomedicines.

Nanomedicine implication in cancer treatment and diagnosis studies witness huge attention, especially with the promising results obtained in preclinical studies. Despite this, only few nanomedicines succeeded to pass clinical phase.

  • Ref: Adv Drug Deliv Rev. 2020 Dec 31:S0169-409X(20)30294-5.
  • Année de publication : 2020
  • Auteurs : Ladaycia A, Loretz B, Passirani C, Lehr CM, Lepeltier E.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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Breast cancer tumor heterogeneity has only little impact on the estimation of the Oncotype DX® recurrence…

Oncotype DX® assay is used to guide therapeutic decisions in early-stage invasive breast carcinoma but remains expensive. Magee Equations (MEs) and Magee Decision Algorithm (MDA) predict the Oncotype DX® recurrence score (RS) on the basis of histopathological parameters.

  • Ref: Hum Pathol. 2020 Nov 24;108:51-59.
  • Année de publication : 2020
  • Auteurs : Remoué A, Conan-Charlet V, Deiana L, Tyulyandina A, Marcorelles P, Schick U, Uguen A.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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Can alternative PET reconstruction schemes improve the prognostic value of radiomic features in non-small cell lung…

Purpose: To evaluate the potential benefit of using alternative reconstruction schemes of PET images for the prognostic value of radiomic features.

Methods: Patients (n=91) with non-small cell lung cancer were prospectively included. All had a PET/CT examination before treatment.

  • Ref: Methods. 2020 Nov 14:S1046-2023(20)30251-6.
  • Année de publication : 2020
  • Auteurs : Tankyevych O, Tixier F, Antonorsi N, Filali Razzouki A, Mondon R, Pinto-Leite T, Visvikis D, Hatt M, Cheze Le Rest C.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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MRI-derived radiomics: methodology and clinical applications in the field of pelvic oncology.

Personalized medicine aims at offering optimized treatment options and improved survival for cancer patients based on individual variability. The success of precision medicine depends on robust biomarkers.

  • Ref: Br J Radiol. 2019 Dec;92(1104):20190105.
  • Année de publication : 2020
  • Auteurs : Schick U, Lucia F, Dissaux G, Visvikis D, Badic B, Masson I, Pradier O, Bourbonne V, Hatt M.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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On the production of 52gMn by deuteron irradiation on natural chromium and its radionuclidic purity.

The positron emitter 52gMn is used for the Positron Emission Tomography – PET imaging.In this work we investigate the nuclear reactions for production of 52gMn and 54Mn induced by deuteron beams on natural chromium targets at energies up to Ed = 28 MeV using the stacked-foils activation technique.

  • Ref: Appl Radiat Isot. 2020 Dec;166:109329.
  • Année de publication : 2020
  • Auteurs : Bianchi F, Marchi C, Fuad G, Groppi F, Haddad F, Magagnin L, Manenti S.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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Targeting Stereotactic Body Radiotherapy on Metabolic PET- and Immuno-PET-Positive Vertebral Metastases.

(1) Background: Stereotactic body radiotherapy (SBRT) for vertebral metastases (VM) allows the delivery of high radiation doses to tumors while sparing the spinal cord. We report a new approach to clinical target volume (CTV) delineation based on anti-carcinoembryonic antigen (CEA) positron emission tomography (pretargeted immuno-PET; “iPET”) in patients with metastatic breast cancer (BC) or medullary thyroid cancer (MTC).

  • Ref: Biomedicines. 2020 Nov 28;8(12):548.
  • Année de publication : 2020
  • Auteurs : Pichon B, Rousseau C, Blanc-Lapierre A, Delpon G, Ferrer L, Libois V, Le Turnier M, Lenoble C, Bodet-Milin C, Goldenberg DM, Kraeber-Bodere F, Supiot S.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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Radiomics analysis of 3D dose distributions to predict toxicity of radiotherapy for lung cancer.

(Chemo)-radiotherapy (RT) is the gold standard treatment for patients with locally advanced lung cancer non accessible for surgery. However, current toxicity prediction models rely on clinical and dose volume histograms (DVHs) and remain unsufficient.

  • Ref: Radiother Oncol. 2020 Nov 6;155:144-150.
  • Année de publication : 2020
  • Auteurs : Bourbonne V, Da-Ano R, Jaouen V, Lucia F, Dissaux G, Bert J, Pradier O, Visvikis D, Hatt M, Schick U.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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Activity of the human immortalized endothelial progenitor cell line HEPC-CB.1 supporting in vitro angiogenesis.

The human HEPC-CB.1 cell line with many characteristics of endothelial progenitor cells (EPC) was tested for its proangiogenic properties as a potentially therapeutic compound. HEPC-CB.1 cells’ potential to differentiate into endothelial cells was revealed after treating the cells with a mixture of ATRA, cAMP and VEGF, as shown by the reduced expression levels of CD133, CD271 and CD90 antigens, augmentation of CD146 and CD31, and a decrease in cell clonogenicity.

  • Ref: doi: 10.1007/s11033-020-05662-6.
  • Année de publication : 2020
  • Auteurs : Kantor A, Krawczenko A, Bielawska-Pohl A, Duś D, Grillon C, Kieda C, Charkiewicz K, Paprocka M
  • Réseaux : Réseaux: « Immunothérapies » & « Niches et Epigénétique des Tumeurs »
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