Les publications

(1) Background: Stereotactic body radiotherapy (SBRT) for vertebral metastases (VM) allows the delivery of high radiation doses to tumors while sparing the spinal cord. We report a new approach to clinical target volume (CTV) delineation based on anti-carcinoembryonic antigen (CEA) positron emission tomography (pretargeted immuno-PET; “iPET”) in patients with metastatic breast cancer (BC) or medullary thyroid cancer (MTC).

Purpose: The aim of this study was to compare retrospectively 18F-DOPA PET/CT versus 68Ga-DOTANOC PET/CT in a group of patients affected by midgut NET.

Patients and methods: Patients with histologically proven grade 1 or grade 2 midgut NET were explored after injection of 150 MBq of 68Ga-DOTANOC and 210 MBq of 18F-DOPA. The PET/CTs were analyzed visually and semiquantitatively at the patient level, regional level (7 defined regions), and lesion level (maximum of 5 lesions/organ).

Image-guided radiotherapy (IGRT) has become a standard irradiation technique to improve the clinical outcome of patients in terms of toxicity and local control due to better targeting of radiation during the irradiation fraction. Positioning imaging systems, whether embedded or not, such as kV for 2×2D acquisitions and especially kVCBCT for 3D acquisitions are however irradiating in a large volume including the target volume but also healthy tissue, with a theoretical risk of increased toxicity and second cancer.

La récidive biologique d’un adénocarcinome de prostate après irradiation est définie selon les critères de Phoenix. Il est nécessaire de prouver une récidive histologique par des biopsies. Le but de cette étude est d’analyser la localisation des récidives et de comparer les biopsies prostatiques transpérinéales en saturation et ciblées, aux index tumoraux (IT) défini sur l’IRM et par le TDM-TEP à la 18F-choline (TEPc).

In standard radiomics studies the features extracted from clinical images are mostly quantified with simple statistics such as the average or variance per Region of Interest (ROI). Such approaches may smooth out any intra-region heterogeneity and thus hide some tumor aggressiveness that may hamper predictions.

Les modalités de surveillance active (SA) d’un adénocarcinome prostatique (CaP) de faible risque intègrent dorénavant les données de l’IRM pour le calcul de la densité du PSA (PSAd) et la réalisation de biopsies ciblées. Le but de cette étude était d’évaluer la proportion de patients pouvant bénéficier d’une SA en fonction de critères pré-biopsiques comme le résultat de l’IRM et la densité du PSA.

Purpose: To evaluate the potential benefit of using alternative reconstruction schemes of PET images for the prognostic value of radiomic features.

Methods: Patients (n=91) with non-small cell lung cancer were prospectively included. All had a PET/CT examination before treatment.

Background: Targeted therapies such as BRAF and MEK inhibitors and immunotherapies have been made available to treat melanoma.

Objectives: To provide an overview of the management of the French Stage III melanoma population after complete lymph node resection prior to new adjuvant therapies.