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375 publications
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Cross-Species Proteomics Identifies CAPG and SBP1 as Crucial Invasiveness Biomarkers in Rat and Human Malignant Mesothelioma.

Malignant mesothelioma (MM) still represents a devastating disease that is often detected too late, while the current effect of therapies on patient outcomes remains unsatisfactory. Invasiveness biomarkers may contribute to improving early diagnosis, prognosis, and treatment for patients, a task that could benefit from the development of high-throughput proteomics.

  • Ref: doi: 10.3390/cancers12092430
  • Année de publication : 2020
  • Auteurs : Nader JS, Boissard A, Henry C, Valo I, Verrièle V, Grégoire M, Coqueret O, Guette C, Pouliquen DL.
  • Réseaux : Réseaux: « Niches et Epigénétique des Tumeurs »
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Bovine Organospecific Microvascular Endothelial Cell Lines as New and Relevant In Vitro Models to Study Viral…

Microvascular endothelial cells constitute potential targets for exogenous microorganisms, in particular for vector-borne pathogens. Their phenotypic and functional variations according to the organs they are coming from provide an explanation of the organ selectivity expressed in vivo by pathogens.

  • Ref: DOI : 10.3390/ijms21155249
  • Année de publication : 2020
  • Auteurs : Lagrée AC, Fasani F, Rouxel C, Pivet M, Pourcelot M, Fablet A, Romey A, Caignard G, Vitour D, Blaise-Boisseau S, Kieda C, Boulouis HJ, Haddad N, Grillon C.
  • Réseaux : Réseaux: « Niches et Epigénétique des Tumeurs »
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Active surveillance in prostate cancer is possible for Afro-Caribbean population: Comparison of oncological outcomes with a…

Prostate cancer is supposedly more aggressive among Afro-Caribbean men. There is a lack of data in this population for active surveillance. Published series are retrospective or have small samples and results are discordant.

  • Ref: doi: 10.1016/j.purol.2020.05.006
  • Année de publication : 2020
  • Auteurs : Percot M, Robert G, Bladou F, Ferrière JM, Bensadoun H, Bernhard JC, Alezra E, Capon G, Sénéchal C, Gourtaud G, Brureau L, Roux V, Blanchet P, Eyraud R
  • Réseaux : Réseaux: « Cancers des Tissus Hormono-dépendants »
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COVID-19 and people followed for breast cancer: French guidelines for clinical practice of Nice-St Paul de…

  • Ref: doi: 10.1016/j.bulcan.2020.03.008
  • Année de publication : 2020
  • Auteurs : Gligorov J, Bachelot T, Pierga JY, Antoine EC, Balleyguier C, Barranger E, Belkacemi Y, Bonnefoi H, Bidard FC, Ceugnart L, Classe JM, Cottu P, Coutant C, Cutuli B, Dalenc F, Darai E, Dieras V, Dohollou N, Giacchetti S, Goncalves A, Hardy-Bessard AC, Houvenaeghel G, Jacquin JP, Jacot W, Levy C, Mathelin C, Nisand I, Petit T, Petit T, Poncelet E, Rivera S, Rouzier R, Salmon R, Scotté F, Spano JP, Uzan C, Zelek L, Spielmann M, Penault-Llorca F, Namer M, Delaloge S
  • Réseaux : Réseaux: « Cancers des Tissus Hormono-dépendants »
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Involvement of the M-CSF/IL-34/CSF-1R pathway in malignant pleural mesothelioma.

Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer related to asbestos exposure. The tumor microenvironment content, particularly the presence of macrophages, was described as crucial for the development of the disease.

  • Ref: doi: 10.1136/jitc-2019-000182
  • Année de publication : 2020
  • Auteurs : Blondy T, d'Almeida SM, Briolay T, Tabiasco J, Meiller C, Chéné AL, Cellerin L, Deshayes S, Delneste Y, Fonteneau JF, Boisgerault N, Bennouna J, Grégoire M, Jean D, Blanquart C
  • Réseaux : Réseaux: « Immunothérapies »
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Contribution of the SYK Tyrosine kinase expression to human iNKT self-reactivity.

Invariant Natural Killer T (iNKT) cells are particular T lymphocytes at the frontier between innate and adaptative immunities. They participate in the elimination of pathogens or tumor cells, but also in the development of allergic reactions and autoimmune diseases. From their first descriptions, the phenomenon of self-reactivity has been described.

  • Ref: doi: 10.1002/eji.201948416
  • Année de publication : 2020
  • Auteurs : Perroteau J, Navet B, Devilder MC, Hesnard L, Scotet E, Gapin L, Saulquin X, Gautreau-Rolland L
  • Réseaux : Réseaux: « Immunothérapies »
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Anti-Glucosylsphingosine Autoimmunity, JAK2V617F-Dependent Interleukin-1β and JAK2V617F-Independent Cytokines in Myeloproliferative Neoplasms.

Inflammatory cytokines play a major role in myeloproliferative neoplasms (MPNs) as regulators of the MPN clone and as mediators of clinical symptoms and complications. Firstly, we investigated the effect of JAK2V617F on 42 molecules linked to inflammation.

  • Ref: doi: 10.3390/cancers12092446
  • Année de publication : 2020
  • Auteurs : Allain-Maillet S, Bosseboeuf A, Mennesson N, Bostoën M, Dufeu L, Choi EH, Cleyrat C, Mansier O, Lippert E, Le Bris Y, Gombert JM, Girodon F, Pettazzoni M, Bigot-Corbel E, Hermouet S
  • Réseaux : Réseaux: « Immunothérapies »
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Analysis of the Targets and Glycosylation of Monoclonal IgAs From MGUS and Myeloma Patients.

Previous studies showed that monoclonal immunoglobulins G (IgGs) of “monoclonal gammopathy of undetermined significance” (MGUS) and myeloma were hyposialylated, thus presumably pro-inflammatory, and for about half of patients, the target of the monoclonal IgG was either a virus-Epstein…

  • Ref: doi: 10.3389/fimmu.2020.00854
  • Année de publication : 2020
  • Auteurs : Bosseboeuf A, Seillier C, Mennesson N, Allain-Maillet S, Fourny M, Tallet A, Piver E, Lehours P, Mégraud F, Berthelot L, Harb J, Bigot-Corbel E, Hermouet S
  • Réseaux : Réseaux: « Immunothérapies »
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Characteristics of MGUS and Multiple Myeloma According to the Target of Monoclonal Immunoglobulins, Glucosylsphingosine, or Epstein-Barr…

: Chronic stimulation by infectious or self-antigens initiates subsets of monoclonal gammopathies of undetermined significance (MGUS), smoldering multiple myeloma (SMM), or multiple myeloma (MM). Recently, glucosylsphingosine (GlcSph) was reported to be the target of one third of monoclonal immunoglobulins (Igs).

  • Ref: doi: 10.3390/cancers12051254
  • Année de publication : 2020
  • Auteurs : Bosseboeuf A, Mennesson N, Allain-Maillet S, Tallet A, Piver E, Decaux O, Moreau C, Moreau P, Lehours P, Mégraud F, Salle V, Bigot-Corbel E, Harb J, Hermouet S
  • Réseaux : Réseaux: « Immunothérapies »
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