Les publications

Retrouvez ici les publications des équipes de recherche du CGO. Page en cours de mise à jour...

338 publications
Année de publication :
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TH1579, MTH1 inhibitor, delays tumour growth and inhibits metastases development in osteosarcoma model.

Background: Osteosarcoma (OS) is the most common primary malignant bone tumour. Unfortunately, no new treatments are approved and over the last 30 years the survival rate remains only 30% at 5 years for poor responders justifying an urgent need of new therapies.

  • Ref: DOI: 10.1016/j.ebiom.2020.102704
  • Année de publication : 2020
  • Auteurs : Brice Moukengue , Hannah K Brown, Céline Charrier , Séverine Battaglia , Marc Baud'huin, Thibaut Quillard , Therese M Pham, Ioannis S Pateras, Vassilis G Gorgoulis, Thomas Helleday, Dominique Heymann, Ulrika Warpman Berglund, Benjamin Ory , Francois Lamoureux
  • Réseaux : Réseaux: Réseau « Niches et Epigénétique des tumeurs »
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Implication of the p53-Related miR-34c, -125b, and -203 in the Osteoblastic Differentiation and the Malignant Transformation…

The formation of the skeleton occurs throughout the lives of vertebrates and is achieved through the balanced activities of two kinds of specialized bone cells: the bone-forming osteoblasts and the bone-resorbing osteoclasts.

  • Ref: DOI: 10.3390/cells9040810
  • Année de publication : 2020
  • Auteurs : Camille Jacques , Robel Tesfaye , Melanie Lavaud , Steven Georges , Marc Baud'huin , François Lamoureux , Benjamin Ory
  • Réseaux : Réseaux: Réseau « Niches et Epigénétique des tumeurs »
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Cell-free circulating epimarks in cancer monitoring

Cancer numbers increasing, cases heterogeneity and the drug resistance emergence have pushed scientists to search for innovative solutions for patients and epimutations can be one. Methylated DNA, modified nucleosomes and noncoding RNAs are found in all cells, including tumor cells.

  • Ref: DOI: 10.2217/epi-2019-0170
  • Année de publication : 2020
  • Auteurs : Manon Duforestel, Joséphine Briand, Gwenola Bougras-Cartron, Dominique Heymann, Jean-Sébastien Frenel, François M Vallette, Pierre-François Cartron
  • Réseaux : Réseaux: Réseau NET
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MicroRNAs in Tumor Exosomes Drive Immune Escape in Melanoma

MicroRNAs (miRNA), small noncoding RNAs that regulate gene expression, exist not only in cells but also in a variety of body fluids. These circulating miRNAs could enable intercellular communication. miRNAs are packaged in membrane-encapsulated vesicles, such as exosomes, or protected by RNA-binding proteins.

  • Ref: DOI: 10.1158/2326-6066.CIR-19-0522
  • Année de publication : 2020
  • Auteurs : Vignard V, Labbé M, Marec N, André-Grégoire G, Jouand N, Fonteneau JF, Labarrière N, Fradin D.
  • Réseaux : Réseaux: Réseau Immunothérapie
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Increased antitumor efficacy of PD-1-deficient melanoma-specific human lymphocytes

Background: Genome editing offers unique perspectives for optimizing the functional properties of T cells for adoptive cell transfer purposes. So far, PDCD1 editing has been successfully tested mainly in chimeric antigen receptor T (CAR-T) cells and human primary T cells.

  • Ref: DOI: 10.1136/jitc-2019-000311
  • Année de publication : 2020
  • Auteurs : Marotte L, Simon S, Vignard V, Dupre E, Gantier M, Cruard J, Alberge JB, Hussong M, Deleine C, Heslan JM, Shaffer J, Beauvais T, Gaschet J, Scotet E, Fradin D, Jarry A, Nguyen T, Labarriere N. J Immunother
  • Réseaux : Réseaux: Réseau Immunothérapie
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New insights on the role of ROS in the mechanisms of sonoporation-mediated gene delivery

Reactive oxygen species (ROS) are hypothesized to play a role in the sonoporation mechanisms. Nevertheless, the acoustical phenomenon behind the ROS production as well as the exact mechanisms of ROS action involved in the increased cell membrane permeability are still not fully understood

  • Ref: DOI: 10.1016/j.ultsonch.2020.104998
  • Année de publication : 2020
  • Auteurs : Escoffre JM, Campomanes P, Tarek M, Bouakaz A.
  • Réseaux : Réseaux: Réseau VIR
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Picolinate-appended tacn complexes for bimodal imaging: Radiolabeling, relaxivity, photophysical and electrochemical studies

Based on our previous works involving two ,4,7-triazacyclononane (tacn)-based ligands Hno2py1pa (1-Picolinic acid-4,7-bis(pyridin-2-ylmethyl)-,4,7-triazacyclononane) and Hno1pa (1-Picolinic acid-,4,7-triazacyclononane)…

  • Ref: DOI: 10.1016/j.jinorgbio.2019.110978
  • Année de publication : 2020
  • Auteurs : Guillou A, Galland M, Roux A, Váradi B, Gogolák RA, Le Saëc P, Faivre-Chauvet A, Beyler M, Bucher C, Tircsó G, Patinec V, Maury O, Tripier R. J
  • Réseaux : Réseaux: Réseau VIR
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microRNAs identified in prostate cancer: Correlative studies on response to ionizing radiation.

As the most frequently diagnosed non-skin cancer in men and a leading cause of cancer-related death, understanding the molecular mechanisms that drive treatment resistance in prostate cancer poses a significant clinical need.

  • Ref: DOI: 10.1186/s12943-020-01186-6
  • Année de publication : 2020
  • Auteurs : Maureen Labbé , Christianne Hoey , Jessica Ray , Vincent Potiron, Stéphane Supiot,, Stanley K Liu, Delphine Fradin
  • Réseaux : Réseaux: Réseau « Niches et Epigénétique des tumeurs »
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