Les publications

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459 publications
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Promising clinical performance of pretargeted immuno-PET.

This pilot study evaluated the imaging performance of pretargeted immunological positron emission tomography (immuno-PET) using an anti-carcinoembryonic antigen (CEA) recombinant bispecific monoclonal antibody (BsMAb), TF2 and the [68Ga]Ga-labelled HSG peptide, IMP288, in patients with metastatic colorectal carcinoma (CRC).

  • Ref: doi: 10.1007/s00259-020-04989-3
  • Année de publication : 2020
  • Auteurs : Touchefeu Y, Bailly C, Frampas E, Eugène T, Rousseau C, Bourgeois M, Bossard C, Faivre-Chauvet A, Rauscher A, Masson D, David A, Cerato E, Carlier T, Sharkey RM, Goldenberg DM, Barbet J, Kraeber-Bodere F, Bodet-Milin C.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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Implementation of a molecular tumor board at a regional level to improve access to targeted therapy.

With the development of precision oncology, Molecular Tumor Boards (MTB) are developing in many institutions. However, the implementation of MTB in routine clinical practice has still not been thoroughly studied.

  • Ref: doi: 10.1007/s10147-020-01661-6
  • Année de publication : 2020
  • Auteurs : Bourien H, Lespagnol A, Campillo-Gimenez B, Felten-Vinot I, Metges JP, Corre R, Lesimple T, le Marechal C, Boussemart L, Kammerer-Jacquet SF, le Gall E, Denoual F, de Tayrac M, Galibert MD, Mosser J, Edeline J.
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Initial Clinical Results of a Novel Immuno-PET Theranostic Probe in HER2-negative Breast Cancer.

This prospective study evaluated the imaging performance of a novel pretargeting immunologic PET (immuno-PET) method in patients with human epidermal growth factor receptor 2 (HER2)-negative, carcinoembryonic antigen (CEA)-positive metastatic breast cancer, compared with CT, bone MRI, and 18F-FDG PET.

  • Ref: doi: 10.2967/jnumed.119.236000
  • Année de publication : 2020
  • Auteurs : Rousseau C, Goldenberg DM, Colombie M, Sebille JC, Meingan P, Ferrer L, Baumgartner P, Cerato E, Masson D, Campone M, Rauscher A, Fleury V, Labbe C, Faivre-Chauvet A, Frenel JS, Toquet C, Barbet J, Sharkey RM, Campion L, Kraeber-Bodere F.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies » & « Cancers des Tissus Hormono-dépendants »
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Exercise training improves radiotherapy efficiency in a murine model of prostate cancer.

Engaging in exercise while undergoing radiotherapy (RT) has been reported to be safe and achievable. The impact of exercise training (ET) on RT efficiency is however largely unknown. Our study aims to investigate the interactions between ET and RT on prostate cancer growth.

  • Ref: doi: 10.1096/fj.201901728R
  • Année de publication : 2020
  • Auteurs : Dufresne S, Guéritat J, Chiavassa S, Noblet C, Assi M, Rioux-Leclercq N, Rannou-Bekono F, Lefeuvre-Orfila L, Paris F, Rébillard A.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies » & « Cancers des Tissus Hormono-dépendants »
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Targeting Tumor Associated Macrophages to Overcome Conventional Treatment Resistance in Glioblastoma.

Glioblastoma (GB) is the most common and devastating form of brain cancer. Despite conventional treatments, progression or recurrences are systematic. In recent years, immunotherapies have emerged as an effective treatment in a number of cancers, leaving the question of their usefulness also faced with the particular case of brain tumors.

  • Ref: doi: 10.3389/fphar.2020.00368
  • Année de publication : 2020
  • Auteurs : Grégoire H, Roncali L, Rousseau A, Chérel M, Delneste Y, Jeannin P, Hindré F, Garcion E.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies » & « Immunothérapies »
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Correlation between fluorodeoxyglucose hotspots on preradiotherapy PET/CT and areas of cancer local relapse.

The aim of the present paper is to systematically review all available literature on preradiotherapy high uptake areas (hotspots) as a potential target for dose escalation in different tumour sites, and to understand the potential role and limitations of fluorodeoxyglucose (FDG)-positron-emission tomography (PET)/computed tomography (CT) in this context.

  • Ref: doi: 10.1016/j.canrad.2020.04.010
  • Année de publication : 2020
  • Auteurs : Abgral R, Bourhis D, Calais J, Lucia F, Leclère JC, Salaün PY, Vera P, Schick U.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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Impact of suboptimal dosimetric coverage of pretherapeutic 18F-FDG PET/CT hotspots on outcome in patients with locally…

Areas of high uptake on pre-treatment 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT), denoted as « hotspots », have been identified as preferential sites of local relapse in locally advanced cervical cancer (LACC).

  • Ref: doi: 10.1016/j.ctro.2020.05.004
  • Année de publication : 2020
  • Auteurs : Lucia F, Bourbonne V, Gujral D, Dissaux G, Miranda O, Mauguen M, Pradier O, Abgral R, Schick U.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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Integration of 18-FDG PET/CT in the Initial Work-Up to Stage Head and Neck Cancer.

The objective of this study was to assess the therapeutic and prognostic impact of integrating18F-fluorodeoxyglucose (18-FDG) positron emission tomography (PET)/computed tomography (CT) into work-up (WU) at initial staging of patients with head and neck squamous cell carcinoma (HNSCC).

  • Ref: doi: 10.3389/fmed.2020.00273
  • Année de publication : 2020
  • Auteurs : Leclere JC, Delcroix O, Rousset J, Valette G, Robin P, Guezennec C, Le Pennec R, Gujral DM, Abgral M, Ollivier L, Marianowski R, Salaun PY, Schick U, Abgral R.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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Performance of 18F-fluorodesoxyglucose positron-emission tomography/computed tomography for cancer screening.

Venous thromboembolism (VTE) may be the first manifestation of cancer. We aimed at evaluating the performance of 18F-Fluorodesoxyglucose Positron-Emission Tomography/Computed Tomography (FDG PET/CT) for occult cancer screening in patients with unprovoked VTE.

  • Ref: doi: 10.1016/j.thromres.2020.06.034
  • Année de publication : 2020
  • Auteurs : Robin P, van Es N, Le Roux PY, Rondina M, Lecumberri R, Beckers M, Le Gal G, Salaun PY.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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