Les publications

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413 publications
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Antibody-Drug Conjugates: The Last Decade.

An armed antibody (antibody-drug conjugate or ADC) is a vectorized chemotherapy, which results from the grafting of a cytotoxic agent onto a monoclonal antibody via a judiciously constructed spacer arm. ADCs have made considerable progress in 10 years.

  • Ref: Pharmaceuticals (Basel). 2020 Sep 14;13(9):245.
  • Année de publication : 2020
  • Auteurs : Joubert N, Beck A, Dumontet C, Denevault-Sabourin C.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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Relationship of Tumor Radiation-absorbed Dose to Survival and Response in Hepatocellular Carcinoma Treated with Transarterial Radioembolization…

In humans, histiocytic sarcoma (HS) is an aggressive cancer involving histiocytes. Its rarity and heterogeneity explain that treatment remains a challenge.

  • Ref: Radiology. 2020 Sep;296(3):673-684.
  • Année de publication : 2020
  • Auteurs : Hermann AL, Dieudonné A, Ronot M, Sanchez M, Pereira H, Chatellier G, Garin E, Castera L, Lebtahi R, Vilgrain V; SARAH Trial Group.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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Planning With Patient-Specific Rectal Sub-Region Constraints Decreases Probability of Toxicity in Prostate Cancer Radiotherapy.

Background: A rectal sub-region (SRR) has been previously identified by voxel-wise analysis in the inferior-anterior part of the rectum as highly predictive of rectal bleeding (RB) in prostate cancer radiotherapy.

  • Ref: Front Oncol. 2020 Sep 11;10:1597.
  • Année de publication : 2020
  • Auteurs : Lafond C, Barateau A, N'Guessan J, Perichon N, Delaby N, Simon A, Haigron P, Mylona E, Acosta O, de Crevoisier R.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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Stratifying patients with intermediate-risk prostate cancer.

Objective: Intermediate-risk prostate cancer regroups heterogeneous patients with different oncologic outcomes. Aim of the study is to validate a novel intermediate-risk subclassification (« magnetic resonance imaging [MRI] subclassification ») that defines favorable and unfavorable diseases based on multiparametric MRI parameters and compare it to NCCN and AUA intermediate-risk subclassifications.

  • Ref: Urol Oncol. 2020 Oct 8:S1078-1439(20)30399-9.
  • Année de publication : 2020
  • Auteurs : Diamand R, Ploussard G, Roumiguié M, Malavaud B, Oderda M, Gontero P, Fourcade A, Fournier G, Benamran D, Iselin C, Fiard G, Descotes JL, Peltier A, Simone G, Roche JB, Roumeguère T, Albisinni S.
  • Réseaux : Réseaux: « Cancers des Tissus Hormono-dépendants »
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Neurofibromin Structure, Functions and Regulation.

Neurofibromin is a large and multifunctional protein encoded by the tumor suppressor gene NF1, mutations of which cause the tumor predisposition syndrome neurofibromatosis type 1 (NF1).

  • Ref: Cells. 2020 Oct 27;9(11):E2365.
  • Année de publication : 2020
  • Auteurs : Bergoug M, Doudeau M, Godin F, Mosrin C, Vallée B, Bénédetti H.
  • Réseaux : Réseaux: « Molécules Marines, Métabolisme et Cancer »
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Phase II Study of Pembrolizumab As First-Line, Single-Drug Therapy for Patients With Unresectable Cutaneous Squamous Cell…

Purpose: To evaluate first-line pembrolizumab monotherapy efficacy and safety in patients with unresectable cutaneous squamous cell carcinomas (CSCCs).

  • Ref: J Clin Oncol. 2020 Sep 10;38(26):3051-3061.
  • Année de publication : 2020
  • Auteurs : Maubec E, Boubaya M, Petrow P, Beylot-Barry M, Basset-Seguin N, Deschamps L, Grob JJ, Dréno B, Scheer- Senyarich I, Bloch-Queyrat C, Leccia MT, Stefan A, Saiag P, Grange F, Meyer N, de Quatrebarbes J, Dinulescu M, Legoupil D, Machet L, Dereure O, Zehou O, Montaudié H, Wierzbicka-Hainaut E, Le Corre Y, Mansard S, Guégan S, Arnault JP, Dalac S, Aubin F, Alloux C, Lopez I, Cherbal S, Tibi A, Lévy V.
  • Réseaux : Réseaux: non classé
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Management of Patients with Node-positive Prostate Cancer at Radical Prostatectomy and Pelvic Lymph Node Dissection.

Context: Optimal management of prostate cancer (PCa) patients with lymph node invasion at radical prostatectomy and pelvic lymph node dissection still remains unclear.

  • Ref: Eur Urol Oncol. 2020 Oct;3(5):565-581.
  • Année de publication : 2020
  • Auteurs : Marra G, Valerio M, Heidegger I, Tsaur I, Mathieu R, Ceci F, Ploussard G, van den Bergh RCN, Kretschmer A, Thibault C, Ost P, Tilki D, Kasivisvanathan V, Moschini M, Sanchez-Salas R, Gontero P, Karnes RJ, Montorsi F, Gandaglia G; EAU-YAU Prostate Cancer Working Party.
  • Réseaux : Réseaux: « Cancers des Tissus Hormono-dépendants »
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γ9δ2T cell diversity and the receptor interface with tumor cells.

γ9δ2T cells play a major role in cancer immune surveillance, yet the clinical translation of their in vitro promise remains challenging.

  • Ref: J Clin Invest. 2020 Sep 1;130(9):4637-4651.
  • Année de publication : 2020
  • Auteurs : Vyborova A, Beringer DX, Fasci D, Karaiskaki F, van Diest E, Kramer L, de Haas A, Sanders J, Janssen A, Straetemans T, Olive D, Leusen J, Boutin L, Nedellec S, Schwartz SL, Wester MJ, Lidke KA, Scotet E, Lidke DS, Heck AJ, Sebestyen Z, Kuball J.
  • Réseaux : Réseaux: non classé
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