Les publications

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391 publications
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FDG-PET/CT, a Promising Exam for Detecting High-Risk Myeloma Patients?

Multiple myeloma (MM) is a haematological neoplasm characterized by a clonal proliferation of malignant plasma cells in the bone marrow. MM is associated with high morbidity and mortality and variable survival, which can be very short for some patients but over 10 years for others.

  • Ref: doi: 10.3390/cancers12061384
  • Année de publication : 2020
  • Auteurs : Michaud-Robert AV, Jamet B, Bailly C, Carlier T, Moreau P, Touzeau C, Bourgeois M, Kraeber-Bodere F, Bodet-Milin C.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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Tyrosine conjugation methods for protein labelling.

Over the last two decades, the development of chemical biology and the need for more defined protein conjugates have fostered active research on new bioconjugation techniques. In particular, a wide range of biorthogonal labelling strategies have been reported to functionalise the phenol side chain of tyrosines (Tyr).

  • Ref: doi: 10.1002/chem.202001992
  • Année de publication : 2020
  • Auteurs : Alvarez Dorta D, Deniaud D, Mével M, Gouin SG.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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Promising clinical performance of pretargeted immuno-PET.

This pilot study evaluated the imaging performance of pretargeted immunological positron emission tomography (immuno-PET) using an anti-carcinoembryonic antigen (CEA) recombinant bispecific monoclonal antibody (BsMAb), TF2 and the [68Ga]Ga-labelled HSG peptide, IMP288, in patients with metastatic colorectal carcinoma (CRC).

  • Ref: doi: 10.1007/s00259-020-04989-3
  • Année de publication : 2020
  • Auteurs : Touchefeu Y, Bailly C, Frampas E, Eugène T, Rousseau C, Bourgeois M, Bossard C, Faivre-Chauvet A, Rauscher A, Masson D, David A, Cerato E, Carlier T, Sharkey RM, Goldenberg DM, Barbet J, Kraeber-Bodere F, Bodet-Milin C.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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Implementation of a molecular tumor board at a regional level to improve access to targeted therapy.

With the development of precision oncology, Molecular Tumor Boards (MTB) are developing in many institutions. However, the implementation of MTB in routine clinical practice has still not been thoroughly studied.

  • Ref: doi: 10.1007/s10147-020-01661-6
  • Année de publication : 2020
  • Auteurs : Bourien H, Lespagnol A, Campillo-Gimenez B, Felten-Vinot I, Metges JP, Corre R, Lesimple T, le Marechal C, Boussemart L, Kammerer-Jacquet SF, le Gall E, Denoual F, de Tayrac M, Galibert MD, Mosser J, Edeline J.
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Initial Clinical Results of a Novel Immuno-PET Theranostic Probe in HER2-negative Breast Cancer.

This prospective study evaluated the imaging performance of a novel pretargeting immunologic PET (immuno-PET) method in patients with human epidermal growth factor receptor 2 (HER2)-negative, carcinoembryonic antigen (CEA)-positive metastatic breast cancer, compared with CT, bone MRI, and 18F-FDG PET.

  • Ref: doi: 10.2967/jnumed.119.236000
  • Année de publication : 2020
  • Auteurs : Rousseau C, Goldenberg DM, Colombie M, Sebille JC, Meingan P, Ferrer L, Baumgartner P, Cerato E, Masson D, Campone M, Rauscher A, Fleury V, Labbe C, Faivre-Chauvet A, Frenel JS, Toquet C, Barbet J, Sharkey RM, Campion L, Kraeber-Bodere F.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies » & « Cancers des Tissus Hormono-dépendants »
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Exercise training improves radiotherapy efficiency in a murine model of prostate cancer.

Engaging in exercise while undergoing radiotherapy (RT) has been reported to be safe and achievable. The impact of exercise training (ET) on RT efficiency is however largely unknown. Our study aims to investigate the interactions between ET and RT on prostate cancer growth.

  • Ref: doi: 10.1096/fj.201901728R
  • Année de publication : 2020
  • Auteurs : Dufresne S, Guéritat J, Chiavassa S, Noblet C, Assi M, Rioux-Leclercq N, Rannou-Bekono F, Lefeuvre-Orfila L, Paris F, Rébillard A.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies » & « Cancers des Tissus Hormono-dépendants »
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Targeting Tumor Associated Macrophages to Overcome Conventional Treatment Resistance in Glioblastoma.

Glioblastoma (GB) is the most common and devastating form of brain cancer. Despite conventional treatments, progression or recurrences are systematic. In recent years, immunotherapies have emerged as an effective treatment in a number of cancers, leaving the question of their usefulness also faced with the particular case of brain tumors.

  • Ref: doi: 10.3389/fphar.2020.00368
  • Année de publication : 2020
  • Auteurs : Grégoire H, Roncali L, Rousseau A, Chérel M, Delneste Y, Jeannin P, Hindré F, Garcion E.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies » & « Immunothérapies »
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Integration of 18-FDG PET/CT in the Initial Work-Up to Stage Head and Neck Cancer.

The objective of this study was to assess the therapeutic and prognostic impact of integrating18F-fluorodeoxyglucose (18-FDG) positron emission tomography (PET)/computed tomography (CT) into work-up (WU) at initial staging of patients with head and neck squamous cell carcinoma (HNSCC).

  • Ref: doi: 10.3389/fmed.2020.00273
  • Année de publication : 2020
  • Auteurs : Leclere JC, Delcroix O, Rousset J, Valette G, Robin P, Guezennec C, Le Pennec R, Gujral DM, Abgral M, Ollivier L, Marianowski R, Salaun PY, Schick U, Abgral R.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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Use of Baseline 18 F-FDG PET/CT to Identify Initial Sub-Volumes Associated With Local Failure After Concomitant…

Locally advanced cervical cancer (CC) patients treated by chemoradiotherapy (CRT) have a significant local recurrence rate. The objective of this work was to assess the overlap between the initial high-uptake sub-volume (V1) on baseline 18F-fluorodeoxyglucose (FDG)…

  • Ref: doi: 10.3389/fonc.2020.00678
  • Année de publication : 2020
  • Auteurs : Lucia F, Miranda O, Abgral R, Bourbonne V, Dissaux G, Pradier O, Hatt M, Schick U.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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