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398 publications
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Implementation of a molecular tumor board at a regional level to improve access to targeted therapy.

With the development of precision oncology, Molecular Tumor Boards (MTB) are developing in many institutions. However, the implementation of MTB in routine clinical practice has still not been thoroughly studied.

  • Ref: doi: 10.1007/s10147-020-01661-6
  • Année de publication : 2020
  • Auteurs : Bourien H, Lespagnol A, Campillo-Gimenez B, Felten-Vinot I, Metges JP, Corre R, Lesimple T, le Marechal C, Boussemart L, Kammerer-Jacquet SF, le Gall E, Denoual F, de Tayrac M, Galibert MD, Mosser J, Edeline J.
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Initial Clinical Results of a Novel Immuno-PET Theranostic Probe in HER2-negative Breast Cancer.

This prospective study evaluated the imaging performance of a novel pretargeting immunologic PET (immuno-PET) method in patients with human epidermal growth factor receptor 2 (HER2)-negative, carcinoembryonic antigen (CEA)-positive metastatic breast cancer, compared with CT, bone MRI, and 18F-FDG PET.

  • Ref: doi: 10.2967/jnumed.119.236000
  • Année de publication : 2020
  • Auteurs : Rousseau C, Goldenberg DM, Colombie M, Sebille JC, Meingan P, Ferrer L, Baumgartner P, Cerato E, Masson D, Campone M, Rauscher A, Fleury V, Labbe C, Faivre-Chauvet A, Frenel JS, Toquet C, Barbet J, Sharkey RM, Campion L, Kraeber-Bodere F.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies » & « Cancers des Tissus Hormono-dépendants »
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Exercise training improves radiotherapy efficiency in a murine model of prostate cancer.

Engaging in exercise while undergoing radiotherapy (RT) has been reported to be safe and achievable. The impact of exercise training (ET) on RT efficiency is however largely unknown. Our study aims to investigate the interactions between ET and RT on prostate cancer growth.

  • Ref: doi: 10.1096/fj.201901728R
  • Année de publication : 2020
  • Auteurs : Dufresne S, Guéritat J, Chiavassa S, Noblet C, Assi M, Rioux-Leclercq N, Rannou-Bekono F, Lefeuvre-Orfila L, Paris F, Rébillard A.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies » & « Cancers des Tissus Hormono-dépendants »
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Targeting Tumor Associated Macrophages to Overcome Conventional Treatment Resistance in Glioblastoma.

Glioblastoma (GB) is the most common and devastating form of brain cancer. Despite conventional treatments, progression or recurrences are systematic. In recent years, immunotherapies have emerged as an effective treatment in a number of cancers, leaving the question of their usefulness also faced with the particular case of brain tumors.

  • Ref: doi: 10.3389/fphar.2020.00368
  • Année de publication : 2020
  • Auteurs : Grégoire H, Roncali L, Rousseau A, Chérel M, Delneste Y, Jeannin P, Hindré F, Garcion E.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies » & « Immunothérapies »
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Correlation Between FDG Hotspots on Pre-radiotherapy PET/CT and Areas of HNSCC Local Relapse.

Several series have already demonstrated that intratumoral subvolumes with high tracer avidity (hotspots) in 18F-flurodesoxyglucose positron-emission tomography (FDG-PET/CT) are preferential sites of local recurrence (LR) in various solid cancers after radiotherapy (RT), becoming potential targets for dose escalation.

  • Ref: doi: 10.3389/fmed.2020.00218
  • Année de publication : 2020
  • Auteurs : Truffault B, Bourhis D, Chaput A, Calais J, Robin P, Le Pennec R, Lucia F, Leclère JC, Gujral DM, Vera P, Salaün PY, Schick U, Abgral R.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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Correlation between fluorodeoxyglucose hotspots on preradiotherapy PET/CT and areas of cancer local relapse.

The aim of the present paper is to systematically review all available literature on preradiotherapy high uptake areas (hotspots) as a potential target for dose escalation in different tumour sites, and to understand the potential role and limitations of fluorodeoxyglucose (FDG)-positron-emission tomography (PET)/computed tomography (CT) in this context.

  • Ref: doi: 10.1016/j.canrad.2020.04.010
  • Année de publication : 2020
  • Auteurs : Abgral R, Bourhis D, Calais J, Lucia F, Leclère JC, Salaün PY, Vera P, Schick U.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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Impact of suboptimal dosimetric coverage of pretherapeutic 18F-FDG PET/CT hotspots on outcome in patients with locally…

Areas of high uptake on pre-treatment 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT), denoted as “hotspots”, have been identified as preferential sites of local relapse in locally advanced cervical cancer (LACC).

  • Ref: doi: 10.1016/j.ctro.2020.05.004
  • Année de publication : 2020
  • Auteurs : Lucia F, Bourbonne V, Gujral D, Dissaux G, Miranda O, Mauguen M, Pradier O, Abgral R, Schick U.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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Use of Baseline 18 F-FDG PET/CT to Identify Initial Sub-Volumes Associated With Local Failure After Concomitant…

Locally advanced cervical cancer (CC) patients treated by chemoradiotherapy (CRT) have a significant local recurrence rate. The objective of this work was to assess the overlap between the initial high-uptake sub-volume (V1) on baseline 18F-fluorodeoxyglucose (FDG)…

  • Ref: doi: 10.3389/fonc.2020.00678
  • Année de publication : 2020
  • Auteurs : Lucia F, Miranda O, Abgral R, Bourbonne V, Dissaux G, Pradier O, Hatt M, Schick U.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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Performance of 18F-fluorodesoxyglucose positron-emission tomography/computed tomography for cancer screening.

Venous thromboembolism (VTE) may be the first manifestation of cancer. We aimed at evaluating the performance of 18F-Fluorodesoxyglucose Positron-Emission Tomography/Computed Tomography (FDG PET/CT) for occult cancer screening in patients with unprovoked VTE.

  • Ref: doi: 10.1016/j.thromres.2020.06.034
  • Année de publication : 2020
  • Auteurs : Robin P, van Es N, Le Roux PY, Rondina M, Lecumberri R, Beckers M, Le Gal G, Salaun PY.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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