Les publications

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375 publications
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Immunobiology of Merkel cell carcinoma.

Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer, which is associated in 80% of cases with the Merkel cell polyomavirus (MCPyV). Advanced stages respond to immune checkpoint inhibitors in 50% of cases.

  • Ref: doi: 10.1097/CCO.0000000000000608
  • Année de publication : 2020
  • Auteurs : Samimi M, Kervarrec T, Touze A.
  • Réseaux : Réseaux: « Immunothérapies »
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Roles of endogenous etherlipids and associated PUFA in the regulation of ion channels and their relevance…

Ether lipids (ELs) are lipids characterized by the presence of either an ether linkage (alkyl lipids) or a vinyl ether linkage [i.e., plasmalogens (Pls)] at the sn1 position of the glycerol backbone, and they are enriched in PUFAs at the sn2 position.

  • Ref: doi: 10.1194/jlr.RA120000634
  • Année de publication : 2020
  • Auteurs : Fontaine D, Figiel S, Felix R, Kouba S, Fromont G, Maheo K, Potier-Cartereau M, Chantome A, Vandier C.
  • Réseaux : Réseaux: « Molécules Marines, Métabolisme et Cancer »
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Lipidic synthetic alkaloids as SK3 channel modulators. Synthesis and biological evaluation of 2-substituted tetrahydropyridine derivatives with…

Small Conductance Calcium (Ca2+)-activated potassium (K+) channels (SKCa) are now proved to be involved in many cancer cell behaviors such as proliferation or migration. The SK3 channel isoform was particularly described in breast cancer where it can be associated with the Orai1 Ca2+ channel to form a complex…

  • Ref: doi: 10.1016/j.ejmech.2019.111854
  • Année de publication : 2020
  • Auteurs : Kouba S, Braire J, Félix R, Chantôme A, Jaffrès PA, Lebreton J, Dubreuil D, Pipelier M, Zhang X, Trebak M, Vandier C, Mathé-Allainmat M, Potier-Cartereau M.
  • Réseaux : Réseaux: « Molécules Marines, Métabolisme et Cancer »
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Autophagy and mitophagy in cancer metabolic remodelling.

Metabolic reprogramming in tumours is now recognized as a hallmark of cancer, participating both in tumour growth and cancer progression. Cancer cells develop global metabolic adaptations allowing them to survive in the low oxygen and nutrient tumour microenvironment.

  • Ref: doi: 10.1016/j.semcdb.2019.05.029
  • Année de publication : 2020
  • Auteurs : Ferro F, Servais S, Besson P, Roger S, Dumas JF, Brisson L.
  • Réseaux : Réseaux: « Molécules Marines, Métabolisme et Cancer »
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Synthesis and evaluation of 7-azaindole derivatives bearing benzocycloalkanone motifs as protein kinase inhibitors.

Protein kinases are important drug targets, especially in the area of oncology. This paper reports the synthesis and biological evaluation of new 7-azaindole derivatives bearing benzocycloalkanone motifs as potential protein kinase inhibitors. Four compounds 8g, 8h, 8i, and 8l were discovered to inhibit cyclin-dependent kinase 9 (CDK9/CyclinT) and/or Haspin kinase in the micromolar to nanomolar range.

  • Ref: DOI: 10.1016/j.bmc.2020.115468
  • Année de publication : 2020
  • Auteurs : Qhobosheane MA, Legoabe LJ, Josselin B, Bach S, Ruchaud S, Petzer JP, Beteck RM.
  • Réseaux : Réseaux: « Molécules Marines, Métabolisme et Cancer »
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Functionalization of 9-thioxanthone at the 1-position: From arylaminoderivatives to [1]benzo(thio)pyrano[4,3,2-de]benzothieno[2,3-b]quinolines of biological interest.

Original 1-amino substituted thioxanthone derivatives were easily prepared from the bare heterocycle by a deprotometalation-iodolysis-copper-catalyzed CN bond formation sequence. This last reaction delivered mono- or/and diarylated products depending on the aniline involved.

  • Ref: DOI: 10.1016/j.bioorg.2019.103347
  • Année de publication : 2020
  • Auteurs : MokhtariBrikci-Nigassa N, Nauton L, Moreau P, Mongin O, Duval RE, Picot L, Thiéry V, Souab M, Baratte B, Ruchaud S, Bach S, Le Guevel R, Bentabed-Ababsa G, Erb W, Roisnel T, Dorcet V, Mongin F.
  • Réseaux : Réseaux: « Molécules Marines, Métabolisme et Cancer »
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Detection of ergosterol by liquid chromatography/electrospray mass spectrometry – investigation of unusual in source reactions.

In the field of natural products, de-replication of complex mixtures has become a usual practice to annotate known compounds and avoid their re-isolation. For this purpose, many groups rely on liquid chromatography coupled to high-resolution mass spectrometry (HPLC/MS) to deduce molecular formulae of compounds allowing comparison with public or in-house databases.

  • Ref: DOI: 10.1002/rcm.8780
  • Année de publication : 2020
  • Auteurs : Ory L, Gentil E, Kumla D, Kijjoa A, Nazih EH, Roullier C.
  • Réseaux : Réseaux: « Molécules Marines, Métabolisme et Cancer »
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