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384 publications
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Hippo/YAP Signaling Pathway: A Promising Therapeutic Target in Bone Paediatric Cancers ?

Osteosarcoma and Ewing sarcoma are the most prevalent bone pediatric tumors. Despite intensive basic and medical research studies to discover new therapeutics and to improve current treatments, almost 40% of osteosarcoma and Ewing sarcoma patients succumb to the disease.

  • Ref: DOI: 10.3390/cancers12030645
  • Année de publication : 2020
  • Auteurs : Sarah Morice , Geoffroy Danieau , Françoise Rédini , Bénédicte Brounais-Le-Royer , Franck Verrecchia
  • Réseaux : Réseaux: « Niches et Epigénétique des Tumeurs »
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Local dose analysis to predict acute and late urinary toxicities after prostate cancer radiotherapy: Assessment of…

To perform bladder dose-surface map (DSM) analysis for (1) identifying symptom-related sub-surfaces (Ssurf) and evaluating their prediction capability of urinary toxicity, (2) comparing DSM with dose-volume map (DVM) (method effect), and (3) assessing the reproducibility of DSM (cohort effect).

  • Ref: doi: 10.1016/j.radonc.2020.02.028
  • Année de publication : 2020
  • Auteurs : Mylona E, Cicchetti A, Rancati T, Palorini F, Fiorino C, Supiot S, Magne N, Crehange G, Valdagni R, Acosta O, de Crevoisier R.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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Secretion of acid sphingomyelinase and ceramide by endothelial cells contributes to radiation-induced intestinal toxicity.

Ceramide-induced endothelial cell apoptosis boosts intestinal stem cell radiosensitivity. However, the molecular connection between these two cellular compartments has not been clearly elucidated.

  • Ref: doi: 10.1158/0008-5472.CAN-19-1527
  • Année de publication : 2020
  • Auteurs : Leonetti D, Estéphan H, Ripoche N, Dubois N, Aguesse A, Gouard S, Brossard L, Chiavassa S, Corre I, Pecqueur C, Neunlist M, Hadchity E, Gaugler MH, Mahé MM, Paris F.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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Towards a Stronger Halogen Bond Involving Astatine: Unexpected Adduct with Bu3 PO Stabilized by Hydrogen Bonding.

The halogen bond is a powerful tool for the molecular design and pushing the limits of its strength is of major interest. Bearing the most potent halogen-bond donor atom, astatine monoiodide (AtI) was recently successfully probed [Nat. Chem. 2018, 10, 428-434].

  • Ref: doi: 10.1002/chem.201905389
  • Année de publication : 2020
  • Auteurs : Liu L, Guo N, Champion J, Graton J, Montavon G, Galland N, Maurice R.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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Mitotic stress-induced secretome primes cancer cells to apoptosis and maximizes paclitaxel response in breast tumors when…

We recently identified a previously unappreciated ability of antimitotics to propagate apoptotic priming across cancer cell populations. The underlying paracrine cytotoxic signal, fueled by undead cells activating the cGAS/STING pathway, is required for in vivo antitumor response and it can be further exploited by delayed, but not synchronous, BCL-xL inhibition.

  • Ref: doi: 10.1080/23723556.2020.1735912
  • Année de publication : 2020
  • Auteurs : Lohard S, Juin PP, Barillé-Nion S.
  • Réseaux : Réseaux: « Cancers des Tissus Hormono-dépendants »
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Apolipoprotein-mediated regulation of lipid metabolism induces distinctive effects in different types of breast cancer cells.

The highest incidence of breast cancer is in the Western world. Several aspects of the Western lifestyle are known risk factors for breast cancer. In particular, previous studies have shown that cholesterol levels can play an important role in the regulation of tumor progression.

  • Ref: doi: 10.1186/s13058-020-01276-9
  • Année de publication : 2020
  • Auteurs : Ben Hassen C, Gutierrez-Pajares JL, Guimaraes C, Guibon R, Pinault M, Fromont G, Frank PG.
  • Réseaux : Réseaux: « Cancers des Tissus Hormono-dépendants »
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The Calcium-Sensing Receptor is A Marker and Potential Driver of Neuroendocrine Differentiation in Prostate Cancer.

The mechanisms underlying neuroendocrine (NE) differentiation in prostate cancer (PCa) remain mostly uncharacterized. Since a deregulated calcium homeostasis has been reported in neuroendocrine prostate cancer (NEPC), we explored herein the link between NE differentiation and the calcium-sensing receptor (CaSR).

  • Ref: doi: 10.3390/cancers12040860
  • Année de publication : 2020
  • Auteurs : Bery F, Cancel M, Chantôme A, Guibon R, Bruyère F, Rozet F, Mahéo K, Fromont G.
  • Réseaux : Réseaux: « Cancers des Tissus Hormono-dépendants »
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Androgen deprivation therapy prescription, blood and bone-density testing in a French population-based study exploring adherence to…

The safety profile of androgen deprivation therapy (ADT) is well known, and cardiovascular and osteoporosis risk factors should be assessed before ADT initiation. In order to examine whether the French Committee of Urologic Oncology Prostate Cancer (PCa) Guidelines were properly followed by clinicians, including urologists,…

  • Ref: doi: 10.23736/S0393-2249.20.03683-8
  • Année de publication : 2020
  • Auteurs : Scailteux LM, Balusson F, Oger E, Vincendeau S, Mathieu R.
  • Réseaux : Réseaux: non classé
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