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404 publications
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Increased antitumor efficacy of PD-1-deficient melanoma-specific human lymphocytes

Background: Genome editing offers unique perspectives for optimizing the functional properties of T cells for adoptive cell transfer purposes. So far, PDCD1 editing has been successfully tested mainly in chimeric antigen receptor T (CAR-T) cells and human primary T cells.

  • Ref: DOI: 10.1136/jitc-2019-000311
  • Année de publication : 2020
  • Auteurs : Marotte L, Simon S, Vignard V, Dupre E, Gantier M, Cruard J, Alberge JB, Hussong M, Deleine C, Heslan JM, Shaffer J, Beauvais T, Gaschet J, Scotet E, Fradin D, Jarry A, Nguyen T, Labarriere N. J Immunother
  • Réseaux : Réseaux: « Immunothérapies »
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New insights on the role of ROS in the mechanisms of sonoporation-mediated gene delivery

Reactive oxygen species (ROS) are hypothesized to play a role in the sonoporation mechanisms. Nevertheless, the acoustical phenomenon behind the ROS production as well as the exact mechanisms of ROS action involved in the increased cell membrane permeability are still not fully understood

  • Ref: DOI: 10.1016/j.ultsonch.2020.104998
  • Année de publication : 2020
  • Auteurs : Escoffre JM, Campomanes P, Tarek M, Bouakaz A.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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Picolinate-appended tacn complexes for bimodal imaging: Radiolabeling, relaxivity, photophysical and electrochemical studies

Based on our previous works involving two ,4,7-triazacyclononane (tacn)-based ligands Hno2py1pa (1-Picolinic acid-4,7-bis(pyridin-2-ylmethyl)-,4,7-triazacyclononane) and Hno1pa (1-Picolinic acid-,4,7-triazacyclononane)…

  • Ref: DOI: 10.1016/j.jinorgbio.2019.110978
  • Année de publication : 2020
  • Auteurs : Guillou A, Galland M, Roux A, Váradi B, Gogolák RA, Le Saëc P, Faivre-Chauvet A, Beyler M, Bucher C, Tircsó G, Patinec V, Maury O, Tripier R. J
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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microRNAs identified in prostate cancer: Correlative studies on response to ionizing radiation.

As the most frequently diagnosed non-skin cancer in men and a leading cause of cancer-related death, understanding the molecular mechanisms that drive treatment resistance in prostate cancer poses a significant clinical need.

  • Ref: DOI: 10.1186/s12943-020-01186-6
  • Année de publication : 2020
  • Auteurs : Maureen Labbé , Christianne Hoey , Jessica Ray , Vincent Potiron, Stéphane Supiot,, Stanley K Liu, Delphine Fradin
  • Réseaux : Réseaux: « Niches et Epigénétique des Tumeurs »
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