Les publications

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407 publications
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Quality of Life Effect of the Anti-CCR4 Monoclonal Antibody Mogamulizumab Versus Vorinostat in Patients With Cutaneous…

Background: Sézary syndrome (SS) and mycosis fungoides (MF), 2 types of cutaneous T-cell lymphoma, cause significant morbidity and adversely affect patients’ quality of life (QoL). The present study assessed the QoL measurement changes in patients receiving mogamulizumab versus vorinostat.

  • Ref: Clin Lymphoma Myeloma Leuk. 2020 Sep 18;S2152-2650(20)30511-5.
  • Auteurs : Porcu P, Hudgens S, Horwitz S, Quaglino P, Cowan R, Geskin L, Beylot-Barry M, Floden L, Bagot M, Tsianakas A, Moskowitz A, Huen A, Dreno B, Dalle S, Caballero D, Leoni M, Dale S, Herr F, Duvic M.
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Need for risk-adapted therapy for malignant ovarian germ cell tumors: A large multicenter analysis of germ…

Malignant ovarian germ cell tumors are rare tumors, affecting young women with a generally favorable prognosis.

  • Ref: Gynecol Oncol. 2020 Sep;158(3):666-672.
  • Année de publication : 2020
  • Auteurs : Derquin F, Floquet A, Hardy-Bessard AC, Edeline J, Lotz JP, Alexandre J, Pautier P, Angeles MA, Delanoy N, Lefeuvre-Plesse C, Cancel M, Treilleux I, Augereau P, Lavoue V, Kalbacher E, Berton Rigaud D, Selle F, Nadeau C, Gantzer J, Joly F, Guillemet C, Pomel C, Favier L, Abdeddaim C, Venat-Bouvet L, Provansal M, Fabbro M, Kaminsky MC, Lortholary A, Lecuru F, Coquard IR, de La Motte Rouge T.
  • Réseaux : Réseaux: non classé
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Feasibility and safety of tailored dosing schedule for eculizumab based on therapeutic drug monitoring: lessons from…

Eculizumab is an anti-C5 monoclonal antibody approved for rare diseases including atypical haemolytic-uraemic syndrome. The maintenance phase dosing regimen is identical for all adult patients: 1200 mg every 2 weeks.

  • Ref: Br J Clin Pharmacol. 2020 Oct 28.
  • Année de publication : 2020
  • Auteurs : Passot C, Sberro-Soussan R, Bertrand D, Caillard S, Schvartz B, Domenger C, Contin-Bordes C, Paintaud G, Halimi JM, Ternant D, Gatault P. Br
  • Réseaux : Réseaux: non classé
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Fluorescent peptide biosensor for probing CDK6 activity in lung cancer cell extracts.

CDK6 kinase regulates cell-cycle progression in G1, together with CDK4, but has cell-, tissue- and developmentally distinct functions associated with transcription, angiogenesis and metabolism.

  • Ref: Chembiochem. 2020 Oct 28.
  • Année de publication : 2020
  • Auteurs : Soamalala J, Diot S, Pellerano M, Blanquart C, Galibert M, Jullian M, Puget K, Morris MC.
  • Réseaux : Réseaux: « Vectorisation, Imagerie, Radiothérapies »
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Prognostic impact of cancer stem cell markers ABCB1, NEO1 and HIST1H2AE in colorectal cancer.

Colon cancer develops according to a defined temporal sequence of genetic and epigenetic molecular events that may primarily affect cancer stem cells.

  • Ref: Am J Transl Res. 2020 Sep 15;12(9):5797-5807.
  • Année de publication : 2020
  • Auteurs : Badic B, Durand S, El Khoury F, De La Grange P, Gentien D, Simon B, Le Jossic-Corcos C, Corcos L.
  • Réseaux : Réseaux: « Niches et Epigénétique des Tumeurs »
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4C3 Human Monoclonal Antibody: A Proof of Concept for Non-pathogenic Proteinase 3 Anti-neutrophil Cytoplasmic Antibodies in…

Granulomatosis with polyangiitis (GPA) is a severe autoimmune vasculitis associated with the presence of anti-neutrophil cytoplasmic antibodies (ANCA) mainly targeting proteinase 3 (PR3), a neutrophilic serine proteinase.

  • Ref: Front Immunol. 2020 Sep 25;11:573040.
  • Année de publication : 2020
  • Auteurs : Granel J, Lemoine R, Morello E, Gallais Y, Mariot J, Drapeau M, Musnier A, Poupon A, Pugnière M, Seren S, Nouar D, Gouilleux-Gruart V, Watier H, Korkmaz B, Hoarau C.
  • Réseaux : Réseaux: « Immunothérapies »
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Molecular description of ANGPT2 associated colorectal carcinoma.

Angiopoietin-2 (ANGPT2) is a prognostic factor in metastatic colorectal cancer (CRC). Nevertheless, it remains to be elucidated which molecular characteristics make up the ANGPT2-related poor-prognosis CRC subset.

  • Ref: Int J Cancer. 2020 Oct 1;147(7):2007-2018.
  • Année de publication : 2020
  • Auteurs : Leclerc-Mercier S, Bodemer C, Bourdon-Lanoy E, Boccara O, Hadj-Rabia S, Hamel-Teillac D, Molina TJ, Fraitag S
  • Réseaux : Réseaux: non classé
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